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  • 人才队伍
  • PI介绍

杨跃进

发布时间:2019-12-10 10:52:33

主任医师

博士生导师

中国医学科学院阜外医院副院长

冠心病中心主任

美国心脏病学院会员(FACC)兼任海峡两岸医药卫生交流协会心血管专业委员会主任委员

中华医学会心血管病分会和北京分会副主任委员

主要研究方向:

1、应用基础研究及临床前研究

1)心室重构和心衰的机制及防治研究

2)存活心肌的识别检测和干预研究

3)冠脉和心肌无再流的机制及防治研究

4)干细胞分化和他汀改良梗死心肌微环境提高移植疗效的研究

2、临床研究和转化应用

1)PCI微创化(TRI)和优化(光学相干断层成像 OCT)

2)强化他汀治疗急性心肌梗死(AMI)的研究

3)中药用于AMI预防无再流的研究

4)干细胞新药“间充质干细胞心梗注射液”治疗AMI的随机安慰剂对照多中心临床试验


Research directions:

1.Applied Basic Researches and Preclinical Studies

1)Mechanisms and prevention/cure of ventricular remodeling and heart failure.

2)Identification and rescue of viable myocardium

3)Mechanisms and prevention/cure of coronary and myocardial no-reflow

4)Differentiation and optimized transplantation of adult stem cells to treat acute myocardial infarction

2.Clinical Studies and Translational Application

1)Optimized protocol of coronary revascularization

2)Intensive statins therapy on AMI

3)Traditional Chinese Medicine on prevention of no-reflow in AMI

4)Clinical trials of stem cell transplantation to treat AMI patients


代表性的SCI文章:

[1]Yang Yue-Jin, Qian Hai-Yan, Huang Ji, Geng Yong-Jian, Gao Run-Lin, Dou Ke-Fei, Yang Guo-Sheng, Li Jian-Jun, Shen Rui, He Zuo-Xiang, Lu Min-Jie, Zhao Shi-Hua. Atorvastatin treatment improves post-infarction microenvironments to facilitate the survivals and activities of implanted mesenchymal stem cells in swine hearts with acute myocardial infarction and reperfusion. Eur Heart J. 2008;29: 1578-1590.( IF 10.0)

[2]Zhao Jing-Lin, Yang Yue-Jin, Pei Wei-Dong, Sun Yu-Hua, You Shi-Jie, Gao Run-Lin. Remote periconditioning reduces myocardial no-reflow by the activation of K(ATP) channel via inhibition of Rho-kinase. Int J Cardiol. 2009;133: 179-184. (IF 6.8)

[3]Yang Yue-Jin, Qian Hai-Yan, Huang Ji, Li Jian-Jun,Gao Run-Lin, Dou Ke-Fei, Yang Guo-Sheng, Willerson James T, Geng Yong-Jian. Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts. Arterioscler Thromb Vasc Biol. 2009;29: 2076-2082. (IF 7.2)

[4]Yang Yue-Jin, Kandzari David E, Gao Zhan, Xu Bo, Chen Ji-Lin, Qiao Shu-Bin, Li Jian-Jun, Qin Xue-Wen, Yao Min, Wu Yong-Jian, Yuan Jin-Qing, Chen Jue, Liu Hai-Bo, Dai Jun, Chen Tao, Wang Yang, Li Wei, Gao Run-Lin. Transradial versus transfemoral method of percutaneous coronary revascularization for unprotected left main coronary artery disease: comparison of procedural and late-term outcomes. JACC Cardiovasc Interv. 2010;3: 1035-1042. (IF 12.8)

[5]Li Xiang-Dong, Yang Yue-Jin, Geng Yong-Jian, Jin Chen, Hu Fen-Huan, Zhao Jin-Lin, Zhang Hai-Tao, Cheng Yu-Tong, Qian Hai-Yan, Wang LL, Zhang BJ, Wu Yi-Ling. Tongxinluo reduces myocardial no-reflow and ischemia-reperfusion injury by stimulating the phosphorylation of eNOS via the PKA pathway. Am J Physiol Heart Circ Physiol. 2010;299: H1255-1261. (IF 3.9)


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