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  • 人才队伍
  • PI介绍

张健

发布时间:2017-12-08 10:24:45

主任医师 医学博士 博士生导师 心衰中心主任、心力衰竭监护病房主任 中华医学会心血管病学分会心力衰竭学组委员兼秘书 中国病理生理学会心血管专业委员会委员 国际心脏研究会(ISHR)中国分会委员 中华预防医学会委员,临床医学组副组长 北京医学会急诊医学分会委员


研究方向:

 

毕业于北京协和医院&阜外心血管病医院,长期从事心血管内科临床与科研工作,早年曾从事心血管病分子机制的研究,主要以分子生物学和生物化学手段进行血管紧张素转换酶基因多态性与高血压伴阻塞性睡眠呼吸暂停综合征发病机理的相关性研究。近几年专注于心肌病和心力衰竭的诊治和发病机制研究,是阜外医院心力衰竭监护病房和诊治中心的创始人之一。做为学术带头人先后完成了国家食品药品监督管理局批准的II期临床预试验和II期临床试验5项,完成国家自然科学基金一项,完成国家科技部、卫生部重点科技攻关课题一项,目前承担国家十二·五项目中“中国心力衰竭注册登记”研究,国家自然科学基金一项(张宇辉),北京市慢性心力衰竭研究重点项目一项等工作。在国内外期刊发表论文近22篇(9篇被收录到SCI,被引证多次),主编著作2部。指导带教研究生多名。一直担任国家自然基金委项目评议人,被多种杂志聘为主要审稿人。

 

I graduated from Fu Wai Hospital, Peking Union Medical College. I am engaging in cardiovascular diseases research and clinical practice over 12 years in Fu Wai Hospital.My study had been concentrated on molecular mechanism of cardiovascular disease, and found that the angiotensin-converting enzyme gene polymorphisms were closely associated with the hypertensive patients with obstructive sleep apnea and played an important role in the pathogenesis of hypertensive patients with obstructive sleep apnea.My study recently focused on clinical practice and pathogenesis of cardiomyopathy and heart failure .As as an investigator or principle investigator,I have completed two projects, One of which was supported by NSFC and the other was national Science and Technology Ministry and National  Health  Ministry. Now I am undertaking a project supported by national 12·5. I and my colleagues have done several clinical trials,including phase I-III.And I has 21publications  on  peer reviewed  journals  and  is  the  first  author  on  most  of  them. I  has  a  paper  published  on  JACC  as  first  author.

 

发表文章:

 

1. Wenting Su,Tao An, Jian Zhang, Yuhui Zhang,et al. Serum albumin is a useful prognostic indicator and adds important information to NT-proBNP in a Chinese cohort of heart failure.Clin Biochem. 2012 May;45(7-8):561-5

 

2. Runlin Gao,Jian Zhang,Liuquan Cheng,et al.A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure. J Am Coll Cardiol 2010. May 4;55(18):1907-14 (共同第一作者)

 

3. Jingmin Zhou, Haiming Shi, Jian Zhang,et al.Rationale and design of the b-blocker in heart failure with normal left ventricular ejection fraction (b-PRESERVE) study. Eur J Heart Failure.2010 Feb;12(2):181-5

 

4. Feng Wang, Jian Zhang, Wei Fang, et al. Evaluation of left ventricular volumes and ejection fraction by gated SPECT and cardiac MRI in patients with dilated cardiomyopathy. Eur J Nuel Med Mol imaging. 2009. 36:1611-1621.

 

5. Shi Guoqing, Zhang Jian, Huang Wenli, et al. Retrospective study on the 116 cases of unidentified sudden death in Yunnan. J Chinese Epidemiology, 2006;27:96-101
 
 研究团队合影:
 

 

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