宋雷

专业方向：各种心血管疾病的常规诊治和介入治疗工作，尤其注重于继发性高血压、难治性高血压、遗传性心肌病的诊疗。作为共同发起人，先后成立国家级心血管精准医学研究两大平台：“中华医学会心血管病学分会精准心血管病学学组”，“中国医疗保健国际交流促进会精准心血管病分会”。在全国范围内，致力于心血管疾病“精准医学”基础研究和临床转化应用。

先后作为子课题负责人承担国家“973项目”、国家“863项目”，作为课题负责人承担科技部“国际科技合作项目”、“国家自然科学基金”等项目； 在Eur Heart J、 Circulation、J Clin Invest 及Science等期刊发表SCI论文60余篇。

办公电话：88322170  邮箱：songlei@fuwaihospital.org

研究方向（中、英文，不限数量）：

1.    心血管疾病的风险因素与危险分层

Risk factors and risk stratification of cardiovasculardiseases

2.    肥厚型心肌病与心肌肥厚的遗传学和分子机制研究

Genetics and molecular mechanism of hypertrophiccardiomyopathy and cardiac hypertrophy

代表性SCI文章（5-10篇，格式如下）：

1.    Zhang C^#,Jiang L, Xu L, Tian J, Liu J, Zhao X, Feng X, Wang D, Zhang Y, Sun K, Xu B,Zhao W, Hui R, Gao R, Yuan J*, Song L*. Implications of N-terminal pro-B-typenatriuretic peptide in patients with three-vessel disease. EurHeart J,2019 Nov 1;40(41):3397-3405

2.    Zhang C^#, TianJ^#, Jiang L, Xu L, Liu J, Zhao X, Feng X, Wang D, Zhang Y, Sun K, XuB, Zhao W, Hui R, Gao R, Yuan J*, Song L*. PrognosticValue of Plasma Big Endothelin-1 Level among Patients with Three-VesselDisease: A Cohort Study. J Atheroscler Thromb, 2019, 26(11):959-969

3.    Qin F^#, Liu K^#,Zhang C^#, Sun X, Zhang Y, Wu Y, Ma W, Wang W, Wu X, Qin Y, Zou Y,Zhou X, Jiang X, Wu H, Hui R, Wang J*, Zhang H*, Song L*. Steroid metabolismgene variants and their genotype-phenotype correlations in Chinese early-onsethypertension patients. Hypertens Res.2019, 42(10):1536-1543.

4.  Zhao X#, Jiang L#, Xu L, Tian J, Xu Y, Zhao Y,Feng X, Wu Y, Zhang Y, Wang D, Sun K, Xu J, Liu R, Xu B, Zhao W, Hui R, Gao R,Song L*, Yuan J*. Predictive value of in-hospital white blood cell count inChinese patients with triple-vessel coronary disease. Eur J Prev Cardiol.2019, 26(8):872-882.

5. Liu K#, Qin F#, Sun X, Zhang Y, Wang J,Wu Y, Ma W, Wang W, Wu X, Qin Y, Zhang H, Zhou X, Wu H, Hui R,Zou Y*, Jiang X*, Song L*. Analysis of the genes involved inMendelian forms of low-renin hypertension in Chinese early-onset hypertensivepatients. J Hypertens, 2018,36(3):502-509.

6.  Zhang C#, ZhangH#, Wu G, Luo X, Zhang C, Zou Y, Wang H, Hui R, Wang J*, Song L*. Titin-TruncatingVariants Increase the Risk of Cardiovascular Death in Patients WithHypertrophic Cardiomyopathy. Can J Cardiol, 2017,33(10):1292-1297.

7.  Wang Y#, Tang Y#,Zou Y, Wang D, Zhu L, Tian T, Wang J, Bao J, Hui R, Kang L, Song L*, Wang J*. Plasmalevel of big endothelin-1 predicts the prognosis in patients with hypertrophiccardiomyopathy. Int J Cardiol, 2017, 243:283-289.

8.  Zhu L#, Zou Y#,Wang Y, Luo X, Sun K, Wang H, Jia L, Liu Y, Zou J, Yuan Z, Hui R, Kang L, SongL*, Wang J*. Prognostic Significance of Plasma High-Sensitivity C-ReactiveProtein in Patients With Hypertrophic Cardiomyopathy. J Am Heart Assoc, 2017, 6(2).pii: e004529.

9.  Zhu L^#, Wang J^#, Wang Y,Jia L, Sun K, Wang H, Zou Y, Tian T, Liu Y, Zou J, Hui R, Yuan Z*, Song L*.Plasma Uric Acid as a Prognostic Marker in Patients With HypertrophicCardiomyopathy. Can J Cardiol, 2015,31(10):1252-1258.  

10.  Wang J#, Wang Y#,Zou Y, Sun K, Wang Z, Ding H, Yuan J, Wei W, Hou Q, Wang H, Liu X, Zhang H, JiY, Zhou X, Sharma RK, Wang D, Ahmad F, Hui R*, Song L*. Malignant effects of multiplerare variants in sarcomere genes on the prognosis of patients with hypertrophiccardiomyopathy. Eur J Heart Fail, 2014, 16(9):950-957.

主要科研项目（省部级及以上）：

主要科研成果（省部级及以上）：

研究团队合影：