王淼教授

课题组简介

主要研究方向是心血管疾病炎症调节机制与新药发现。发表主要论文于Nature Communications、PNAS、Circulation（2008, 2011, 2017）、Circulartion Research、J Clin Invest、ATVB、British J Pharmacology等学术期刊。主编《冠心病：治疗与药物发现》英文书（Springer出版社）

代表性SCI文章

1. Zhang Y, Steinmetz-Späh J, Idborg H, Zhu L, Li H, Rao H, Chen Z, Guo Z, Hu L, Xu C, Chen H, Korotkova M, Jakobsson PJ*, Wang M* (*通讯作者). Microsomal prostaglandin E synthase-1 inhibition prevents adverse cardiac remodeling after myocardial infarction in mice. Br J Pharmacol. 2023; doi: 10.1111/bph.16061.

2. Wan Q, Xu C, Zhu L, Zhang Y, Peng Z, Chen H, Rao H, Zhang E, Wang H, Chu F, Ning X, Yang X, Yuan J, Wu Y, Huang Y, Hu S, Liu DP, Wang M* (*通讯作者). Targeting PDE4B (Phosphodiesterase-4 Subtype B) for Cardioprotection in Acute Myocardial Infarction via Neutrophils and Microcirculation. Circ Res. 2022;131(5):442-55.

3. Zhu L, Xu C, Huo X, Hao H, Wan Q, Chen H, Zhang X, Breyer RM, Huang Y, Cao X, Liu DP, FitzGerald GA, Wang M* (*通讯作者). The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. Nat Commun. 2019;10(1):1888.

4. Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M* (*通讯作者). Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arterioscler Thromb Vasc Biol. 2018;38(5):1115-1124.

5. Hao H, Hu S, Chen H, Bu D, Zhu L, Xu C, Chu F, Huo X, Tang Y, Sun X, Ding B, Liu D, Hu S, Wang M* (*通讯作者). Loss of Endothelial CXCR7 Impairs Vascular Homeostasis, and Cardiac Remodeling After Myocardial Infarction: Implications for Cardiovascular Drug Discovery. Circulation. 2017; 135(13):1253-1264.

研究团队合照